Antisense oligonucleotide gapmers containing phosphoryl guanidine groups reverse MDR1-mediated multiple drug resistance of tumor cells

Antisense oligonucleotide gapmers containing phosphoryl guanidine groups reverse MDR1-mediated multiple drug resistance of tumor cells Full article

Journal

MOLECULAR THERAPY-NUCLEIC ACIDS
ISSN: 2162-2531

Output data

Year: 2022, Volume: 27, Pages: 211-226 Pages count : 16 DOI: 10.1016/j.omtn.2021.11.025

Tags

antisense oligonucleotide gapmer; gene silencing; intracellular accumulation; MDR1; nuclease resistance; phosphoryl guanidine; RNase H

Authors

Kupryushkin Maxim S. ¹ , Filatov Anton V. ¹ , Mironova Nadezhda L. ¹ , Patutina Olga A. ¹ , Chernikov Ivan V. ¹ , Chernolovskaya Elena L. ¹ , Zenkova Marina A. ¹ , Pyshnyi Dmitrii V. ¹ , Stetsenko Dmitry A. ^2,3 , Altman Sidney ^4,5,6 , Vlassov Valentin V. ¹

Affiliations

1	Institute of Chemical Biology and Fundamental Medicine SB RAS, Lavrentiev Ave., 8, Novosibirsk 630090, Russia
2	Department of Physics, Novosibirsk State University, Pirogov Str. 2, Novosibirsk 630090, Russia
3	Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Ave. 10, Novosibirsk 630090, Russia
4	Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
5	Life Sciences, Arizona State University, Tempe, AZ 85281, USA
6	Montreal Clinical Research Institute, Montreal QC H2W 1R7, Canada

Funding (3)

1	Institute of Chemical Biology and Fundamental Medicine SB RAS	12
2	МИНИСТЕРСТВО НАУКИ И ВЫСШЕГО ОБРАЗОВАНИЯ РОССИЙСКОЙ ФЕДЕРАЦИИ	ПФНИ РФ (2021-2030) 0245-2021-0007
3	Russian Science Foundation	РНФ №19-74-30011

Kupryushkin M.S. , Filatov A.V. , Mironova N.L. , Patutina O.A. , Chernikov I.V. , Chernolovskaya E.L. , Zenkova M.A. , Pyshnyi D.V. , Stetsenko D.A. , Altman S. , Vlassov V.V.
Antisense oligonucleotide gapmers containing phosphoryl guanidine groups reverse MDR1-mediated multiple drug resistance of tumor cells
MOLECULAR THERAPY-NUCLEIC ACIDS. 2022. V.27. P.211-226. DOI: 10.1016/j.omtn.2021.11.025 WOS Scopus РИНЦ OpenAlex

Submitted:	Jul 9, 2021
Accepted:	Nov 28, 2021
Published online:	Nov 29, 2021

Web of science:	WOS:000766650400007
Scopus:	2-s2.0-85121217937
Elibrary:	47541787
OpenAlex:	W3214943347

DB	Citing
Scopus	15
Elibrary	12
Web of science	20
OpenAlex	19