Base Excision DNA Repair in Plants: Arabidopsis and Beyond
Review
| Journal |
International Journal of Molecular Sciences
, E-ISSN: 1422-0067
|
| Output data |
Year: 2023,
Volume: 24,
Number: 19,
Article number
: 14746,
Pages count
:
DOI:
10.3390/ijms241914746
|
| Tags |
DNA damage; DNA repair; base excision repair; plants |
| Authors |
Grin I.R.
1,2
,
Petrova D.V.
1
,
Endutkin A.V.
1
,
Chunquan M.
3,4,5
,
Bing Y.
3,4,5
,
Haiying L.
3,4,5
,
Zharkov D.O.
1,2
|
| Affiliations |
| 1 |
Siberian Branch of the Russian Academy of Sciences Institute of Chemical Biology and Fundamental Medicine, 8 Lavrentieva Ave., 630090 Novosibirsk, Russia
|
| 2 |
Department of Natural Sciences, Novosibirsk State University, 2 Pirogova St., 630090 Novosibirsk, Russia
|
| 3 |
Engineering Research Center of Agricultural Microbiology Technology, Ministry of Education, Harbin 150080, China
|
| 4 |
Heilongjiang Provincial Key Laboratory of Plant Genetic Engineering and Biological Fermentation Engineering for Cold Region, Harbin 150080, China
|
| 5 |
School of Life Sciences, Heilongjiang University, Harbin 150080, China
|
|
Funding (1)
|
1
|
МИНИСТЕРСТВО НАУКИ И ВЫСШЕГО ОБРАЗОВАНИЯ РОССИЙСКОЙ ФЕДЕРАЦИИ
|
ПФНИ РФ (2021-2030) 0245-2021-0002
|
Base excision DNA repair (BER) is a key pathway safeguarding the genome of all living
organisms from damage caused by both intrinsic and environmental factors. Most present knowledge
about BER comes from studies of human cells, E. coli, and yeast. Plants may be under an even heavier
DNA damage threat from abiotic stress, reactive oxygen species leaking from the photosynthetic
system, and reactive secondary metabolites. In general, BER in plant species is similar to that
in humans and model organisms, but several important details are specific to plants. Here, we
review the current state of knowledge about BER in plants, with special attention paid to its unique
features, such as the existence of active epigenetic demethylation based on the BER machinery, the
unexplained diversity of alkylation damage repair enzymes, and the differences in the processing of
abasic sites that appear either spontaneously or are generated as BER intermediates. Understanding
the biochemistry of plant DNA repair, especially in species other than the Arabidopsis model, is
important for future efforts to develop new crop varieties