Base Excision DNA Repair in Plants: Arabidopsis and Beyond

Base Excision DNA Repair in Plants: Arabidopsis and Beyond Review

Journal

International Journal of Molecular Sciences
, E-ISSN: 1422-0067

Output data

Year: 2023, Volume: 24, Number: 19, Article number : 14746, Pages count : DOI: 10.3390/ijms241914746

Tags

DNA damage; DNA repair; base excision repair; plants

Authors

Grin I.R. ^1,2 , Petrova D.V. ¹ , Endutkin A.V. ¹ , Chunquan M. ^3,4,5 , Bing Y. ^3,4,5 , Haiying L. ^3,4,5 , Zharkov D.O. ^1,2

Affiliations

1	Siberian Branch of the Russian Academy of Sciences Institute of Chemical Biology and Fundamental Medicine, 8 Lavrentieva Ave., 630090 Novosibirsk, Russia
2	Department of Natural Sciences, Novosibirsk State University, 2 Pirogova St., 630090 Novosibirsk, Russia
3	Engineering Research Center of Agricultural Microbiology Technology, Ministry of Education, Harbin 150080, China
4	Heilongjiang Provincial Key Laboratory of Plant Genetic Engineering and Biological Fermentation Engineering for Cold Region, Harbin 150080, China
5	School of Life Sciences, Heilongjiang University, Harbin 150080, China

Funding (1)

МИНИСТЕРСТВО НАУКИ И ВЫСШЕГО ОБРАЗОВАНИЯ РОССИЙСКОЙ ФЕДЕРАЦИИ

ПФНИ РФ (2021-2030) 0245-2021-0002

Base excision DNA repair (BER) is a key pathway safeguarding the genome of all living organisms from damage caused by both intrinsic and environmental factors. Most present knowledge about BER comes from studies of human cells, E. coli, and yeast. Plants may be under an even heavier DNA damage threat from abiotic stress, reactive oxygen species leaking from the photosynthetic system, and reactive secondary metabolites. In general, BER in plant species is similar to that in humans and model organisms, but several important details are specific to plants. Here, we review the current state of knowledge about BER in plants, with special attention paid to its unique features, such as the existence of active epigenetic demethylation based on the BER machinery, the unexplained diversity of alkylation damage repair enzymes, and the differences in the processing of abasic sites that appear either spontaneously or are generated as BER intermediates. Understanding the biochemistry of plant DNA repair, especially in species other than the Arabidopsis model, is important for future efforts to develop new crop varieties

Grin I.R. , Petrova D.V. , Endutkin A.V. , Chunquan M. , Bing Y. , Haiying L. , Zharkov D.O.
Base Excision DNA Repair in Plants: Arabidopsis and Beyond
International Journal of Molecular Sciences. 2023. V.24. N19. 14746 . DOI: 10.3390/ijms241914746 WOS Scopus PMID OpenAlex

Published print:

Sep 29, 2023

Web of science:	WOS:001084645600001
Scopus:	2-s2.0-85174698337
PMID:	37834194
OpenAlex:	W4387168962

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