Fork- and Comb-like Lipophilic Structures: Different Chemical Approaches to the Synthesis of Oligonucleotides with Multiple Dodecyl Residues Научная публикация
| Журнал |
International Journal of Molecular Sciences
, E-ISSN: 1422-0067 |
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| Вых. Данные | Год: 2023, Том: 24, Номер: 19, Номер статьи : 14637, Страниц : DOI: 10.3390/ijms241914637 | ||
| Ключевые слова | lipophilic oligonucleotides; phosphoryl guanidine; triazinyl phosphoramidate; conjugates; delivery | ||
| Авторы |
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| Организации |
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Информация о финансировании (2)
| 1 | МИНИСТЕРСТВО НАУКИ И ВЫСШЕГО ОБРАЗОВАНИЯ РОССИЙСКОЙ ФЕДЕРАЦИИ | ПФНИ РФ (2021-2030) 0245-2021-0007 |
| 2 | Российский научный фонд | РНФ №19-14-00204 (продление) |
Реферат:
Lipophilic oligonucleotide conjugates represent a powerful tool for nucleic acid cellular
delivery, and many methods for their synthesis have been developed over the past few decades. In
the present study, a number of chemical approaches for the synthesis of different fork- and comb-like
dodecyl-containing oligonucleotide structures were performed, including use of non-nucleotide
units and different types of phosphate modifications such as alkyl phosphoramidate, phosphoryl
guanidine, and triazinyl phosphoramidate. The influence of the number of introduced lipophilic
residues, their mutual arrangement, and the type of formed modification backbone on cell penetration
was evaluated. The results obtained indicate great potential in the developed chemical approaches,
not only for the synthesis of complex oligonucleotide structures but also for the fine-tuning of
their properties
Библиографическая ссылка:
Zharkov T.D.
, Mironova E.M.
, Markov O.V.
, Zhukov S.
, Khodyreva S.N.
, Kupryushkin M.S.
Fork- and Comb-like Lipophilic Structures: Different Chemical Approaches to the Synthesis of Oligonucleotides with Multiple Dodecyl Residues
International Journal of Molecular Sciences. 2023. V.24. N19. 14637 . DOI: 10.3390/ijms241914637 WOS Scopus OpenAlex
Fork- and Comb-like Lipophilic Structures: Different Chemical Approaches to the Synthesis of Oligonucleotides with Multiple Dodecyl Residues
International Journal of Molecular Sciences. 2023. V.24. N19. 14637 . DOI: 10.3390/ijms241914637 WOS Scopus OpenAlex
Даты:
| Опубликована в печати: | 27 сент. 2023 г. |
Идентификаторы БД:
| Web of science: | WOS:001081466000001 |
| Scopus: | 2-s2.0-85174748159 |
| OpenAlex: | W4387139031 |