Bronchial asthma, airway remodeling and lung fibrosis as successive steps of one process Review
| Journal |
International Journal of Molecular Sciences
, E-ISSN: 1422-0067 |
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|---|---|---|---|
| Output data | Year: 2023, Volume: 24, Article number : 16042, Pages count : DOI: 10.3390/ijms242216042 | ||
| Tags | asthma; airway remodeling; lung fibrosis; in vivo models; biomarkers | ||
| Authors |
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| Affiliations |
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Funding (2)
| 1 | МИНИСТЕРСТВО НАУКИ И ВЫСШЕГО ОБРАЗОВАНИЯ РОССИЙСКОЙ ФЕДЕРАЦИИ | ПФНИ РФ (2021-2030) 0245-2021-0004 |
| 2 | Russian Science Foundation | РНФ №19-74-30011 |
Abstract:
Bronchial asthma is a heterogeneous disease characterized by persistent respiratory system inflammation, airway hyperreactivity, and airflow obstruction. Airway remodeling, defined
as changes in airway wall structure such as extensive epithelial damage, airway smooth muscle
hypertrophy, collagen deposition, and subepithelial fibrosis, is a key feature of asthma. Lung fibrosis
is a common occurrence in the pathogenesis of fatal and long-term asthma, and it is associated with
disease severity and resistance to therapy. It can thus be regarded as an irreversible consequence
of asthma-induced airway inflammation and remodeling. Asthma heterogeneity presents several
diagnostic challenges, particularly in distinguishing between chronic asthma and other pulmonary
diseases characterized by disruption of normal lung architecture and functions, such as chronic
obstructive pulmonary disease. The search for instruments that can predict the development of
irreversible structural changes in the lungs, such as chronic components of airway remodeling and
fibrosis, is particularly difficult. To overcome these challenges, significant efforts are being directed
toward the discovery and investigation of molecular characteristics and biomarkers capable of distinguishing between different types of asthma as well as between asthma and other pulmonary
disorders with similar structural characteristics. The main features of bronchial asthma etiology,
pathogenesis, and morphological characteristics as well as asthma-associated airway remodeling
and lung fibrosis as successive stages of one process will be discussed in this review. The most
common murine models and biomarkers of asthma progression and post-asthmatic fibrosis will also
be covered. The molecular mechanisms and key cellular players of the asthmatic process described
and systematized in this review are intended to help in the search for new molecular markers and
promising therapeutic targets for asthma prediction and therapy
Cite:
Savin I.A.
, Zenkova M.A.
, Sen'kova A.V.
Bronchial asthma, airway remodeling and lung fibrosis as successive steps of one process
International Journal of Molecular Sciences. 2023. V.24. 16042 . DOI: 10.3390/ijms242216042 WOS Scopus PMID OpenAlex
Bronchial asthma, airway remodeling and lung fibrosis as successive steps of one process
International Journal of Molecular Sciences. 2023. V.24. 16042 . DOI: 10.3390/ijms242216042 WOS Scopus PMID OpenAlex
Dates:
| Published print: | Nov 7, 2023 |
Identifiers:
| Web of science: | WOS:001113338200001 |
| Scopus: | 2-s2.0-85177787626 |
| PMID: | 38003234 |
| OpenAlex: | W4388446641 |