Effect of Usnic Acid-Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitor Used as Monotherapy or in Combination with Olaparib on Transplanted Tumors in vivo

Effect of Usnic Acid-Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitor Used as Monotherapy or in Combination with Olaparib on Transplanted Tumors in vivo Full article

Journal

Molecular Biology
ISSN: 0026-8933

Output data

Year: 2023, Volume: 57, Number: 2, Pages: 220-231 Pages count : 12 DOI: 10.1134/S0026893323020127

Authors

Kornienko T.E. ¹ , Zakharenko A.L. ¹ , Ilina E.S. ^1,4 , Chepanova A.A. ¹ , Zakharova O. ¹ , Dyrkheeva N.S. ¹ , Popova N.A. ^2,4 , Nikolin V.P. ² , Filimonov A.S. ³ , Luzina O.A. ³ , Salakhutdinov N.F. ^3,4 , Lavrik O.I. ^1,4

Affiliations

1	Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090 Russia
2	Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090 Russia
3	Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090 Russia
4	Novosibirsk State University, Novosibirsk, 630090 Russia

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that removes various adducts from the 3' end of DNA. Such adducts are formed by enzymes that introduce single-strand breaks in DNA during catalysis (for example, topoisomerase 1) and a number of anticancer drugs with different mechanisms of action. Poly(ADP-ribose) polymerase 1 (PARP1) is an enzyme that catalyzes posttranslational modification (PARylation) of various targets and thus controls many cell processes, including DNA repair. Tdp1 is a PARP1 target, and its PARylation attracts Tdp1 to the site of DNA damage. Olaparib is a PARP1 inhibitor used in clinical practice to treat homologous recombination-deficient tumors. Olaparib inhibits PARylation and, therefore, DNA repair. The Tdp1 inhibitor OL7-43 was used in combination with olaparib to increase the antitumor effect of the latter. Olaparib cytotoxicity was found to increase in the presence of OL7-43 in vitro. OL7-43 did not exert a sensitizing effect, but showed its own antitumor and antimetastatic effects in Lewis and Krebs-2 carcinoma models.

Kornienko T.E. , Zakharenko A.L. , Ilina E.S. , Chepanova A.A. , Zakharova O. , Dyrkheeva N.S. , Popova N.A. , Nikolin V.P. , Filimonov A.S. , Luzina O.A. , Salakhutdinov N.F. , Lavrik O.I.
Effect of Usnic Acid-Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitor Used as Monotherapy or in Combination with Olaparib on Transplanted Tumors in vivo
Molecular Biology. 2023. V.57. N2. P.220-231. DOI: 10.1134/S0026893323020127 WOS Scopus OpenAlex

Корниенко Т.Е. , Захаренко А.Л. , Ильина Е.С. , Чепанова А.А. , Захарова О.Д. , Дырхеева Н.С. , Попова Н.А. , Николин В.П. , Филимонов А.С. , Лузина О.А. , Салахутдинов Н.Ф. , Лаврик О.И.
Влияние производного усниновой кислоты (ингибитора тирозил-ДНК-фосфодиэстеразы 1) на трансплантированные опухоли in vivo в качестве монотерапии и в сочетании с олапарибом
Молекулярная биология. 2023. Т.57. №2. С.220-231. DOI: 10.31857/S0026898423020143 РИНЦ OpenAlex

Published print:

Apr 26, 2023

Web of science:	WOS:000984409600007
Scopus:	2-s2.0-85156165338
OpenAlex:	W4367056603

DB	Citing
OpenAlex	2
Scopus	1