Increased Frequencies of the ‒174G and ‒572C IL6 Alleles in Populations of Indigenous Peoples of Siberia Compared to Russians

Increased Frequencies of the ‒174G and ‒572C IL6 Alleles in Populations of Indigenous Peoples of Siberia Compared to Russians Full article

Journal

Molecular Biology
ISSN: 0026-8933

Output data

Year: 2023, Volume: 57, Number: 2, Pages: 329-337 Pages count : 9 DOI: 10.1134/s002689332302019x

Tags

cytokines, IL6, genetic polymorphism, rs1800795, rs1800796, real-time PCR, Siberian indigenous peoples, Buryats, Teleuts, Yakuts, Dolgans, Tuvinians, Russians

Authors

Tabikhanova L.E. ¹ , Osipova L.P. ¹ , Churkina T.V. ¹ , Kovalev S.S. ¹ , Filipenko M.L. ² , Voronina E.N. ²

Affiliations

1	Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
2	Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia

The study of immune response and inflammation gene polymorphisms in a genogeographic context is relevant in the study of human populations. Here, in the indigenous populations of Siberia the frequencies of polymorphic variants ‒174G/C (rs1800795) and ‒572C/G (rs1800796) of the IL6 gene encoding the proinflammatory cytokine IL-6 were determined. For the first time, it was shown that the frequencies of the ‒174G and ‒572C alleles, which determine increased inflammatory response and are also associated with several diseases were statistically significantly higher in ethnic groups of Buryats, Teleuts, Yakuts, Dolgans and Tuvinians than in Russians living in Siberia. These values were in the intermediate position between those in the European and East-Asian groups. We hypothesize an adaptive role of these IL6 genetic variants in human settlement from Africa to the Eurasian continent. However, due to the departure from the traditional way of life and the increasing anthropogenic environmental pollution, the risk of diseases whose pathogenesis is based on inflammation in indigenous Siberian populations is likely increased.

Tabikhanova L.E. , Osipova L.P. , Churkina T.V. , Kovalev S.S. , Filipenko M.L. , Voronina E.N.
Increased Frequencies of the ‒174G and ‒572C IL6 Alleles in Populations of Indigenous Peoples of Siberia Compared to Russians
Molecular Biology. 2023. V.57. N2. P.329-337. DOI: 10.1134/s002689332302019x WOS Scopus OpenAlex

Табиханова Л.Э. , Осипова Л.П. , Чуркина Т.В. , Ковалев С.С. , Филипенко М.Л. , Воронина Е.Н.
Повышенные частоты аллелей ‒174G и ‒572C гена IL6 в популяциях коренных народов Сибири по сравнению с русскими
Молекулярная биология. 2023. Т.57. №2. С.350-359. DOI: 10.31857/S0026898423020210 РИНЦ OpenAlex

Published print:

Sep 29, 2022

Web of science:	WOS:000984409600018
Scopus:	2-s2.0-85156144628
OpenAlex:	W4367056844

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