Alternative Mechanisms of Mutagenesis at mCpG Sites during Replication and Repair Review
| Journal |
Molecular Biology
ISSN: 0026-8933 |
||||||
|---|---|---|---|---|---|---|---|
| Output data | Year: 2023, Volume: 57, Number: 4, Pages: 584-592 Pages count : 9 DOI: 10.1134/s0026893323040155 | ||||||
| Tags | 5-methyl-2'-deoxycytidine, CpG sites, DNA polymerases, DNA lesions, repair | ||||||
| Authors |
|
||||||
| Affiliations |
|
Funding (1)
| 1 | МИНИСТЕРСТВО НАУКИ И ВЫСШЕГО ОБРАЗОВАНИЯ РОССИЙСКОЙ ФЕДЕРАЦИИ | ПФНИ РФ (2021-2030) 0245-2021-0002 |
Abstract:
—5-Methyl-2'-deoxycytidine (mC) at CpG sites plays a key role in the epigenetic gene regulation,
cell differentiation, and carcinogenesis. Despite the importance of mC for normal cell function, CpG dinucleotides are known as mutagenesis hotspots. Deamination of mC yields T, causing C→T transitions. However, several recent studies demonstrated the effect of epigenetic modifications of C on the fidelity and efficiency of DNA polymerases and excision repair enzymes. The review summarizes the available data that indicate the existence of deamination-independent mechanisms of mutagenesis at CpG sites.
Cite:
Shilkin E.S.
, Petrova D.V.
, Zharkov D.O.
, Makarova A.V.
Alternative Mechanisms of Mutagenesis at mCpG Sites during Replication and Repair
Molecular Biology. 2023. V.57. N4. P.584-592. DOI: 10.1134/s0026893323040155 WOS Scopus OpenAlex
Alternative Mechanisms of Mutagenesis at mCpG Sites during Replication and Repair
Molecular Biology. 2023. V.57. N4. P.584-592. DOI: 10.1134/s0026893323040155 WOS Scopus OpenAlex
Original:
Шилкин Е.С.
, Петрова Д.В.
, Жарков Д.О.
, Макарова А.В.
Альтернативные механизмы мутагенеза в mCpG сайтах при репликации и репарации
Молекулярная биология. 2023. Т.57. №4. С.587-596. DOI: 10.31857/S0026898423040195 РИНЦ PMID OpenAlex
Альтернативные механизмы мутагенеза в mCpG сайтах при репликации и репарации
Молекулярная биология. 2023. Т.57. №4. С.587-596. DOI: 10.31857/S0026898423040195 РИНЦ PMID OpenAlex
Dates:
| Accepted: | Feb 8, 2023 |
Identifiers:
| Web of science: | WOS:001044476200003 |
| Scopus: | 2-s2.0-85168264715 |
| OpenAlex: | W4385650581 |