Sterile Fecal Microbiota Transplantation Boosts Anti-Inflammatory T-Cell Response in Ulcerative Colitis Patients

Sterile Fecal Microbiota Transplantation Boosts Anti-Inflammatory T-Cell Response in Ulcerative Colitis Patients Научная публикация

Журнал

International Journal of Molecular Sciences
, E-ISSN: 1422-0067

Вых. Данные

Год: 2024, Том: 25, Номер: 3, Номер статьи : 1886, Страниц : DOI: 10.3390/ijms25031886

Ключевые слова

ulcerative colitis; sterile fecal microbiota transplantation; regulatory T cells; immune response

Авторы

Chechushkov Anton ^1,2 , Desyukevich Pavel ² , Yakovlev Timur ² , Al Allaf Lina ² , Shrainer Evgeniya ^3,2 , Morozov Vitalyi ² , Tikunova Nina ^4,2

Организации

1	Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia
2	Federal State Public Scientific Institution “Institute of Chemical Biology and Fundamental Medicine”, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia
3	Autonomous Non-Commercial Organization “Center of New Medical Technologies in Akademgorodok”, 630090 Novosibirsk, Russia
4	Advanced Engineering School, Novosibirsk State University, 630090 Novosibirsk, Russia

Информация о финансировании (2)

1	МИНИСТЕРСТВО НАУКИ И ВЫСШЕГО ОБРАЗОВАНИЯ РОССИЙСКОЙ ФЕДЕРАЦИИ	ПФНИ РФ (2021-2030) 0245-2021-0008
2	Российский научный фонд	РНФ № 21-14-00360

Ulcerative colitis is a chronic immune-mediated disease of unclear etiology, affecting people of different ages and significantly reducing the quality of life. Modern methods of therapy are mainly represented by anti-inflammatory drugs and are not aimed at a specific pathogenetic factor. In this study, we investigated the effect of transplantation of sterile stool filtrate from healthy donors on the induction of anti-inflammatory immune mechanisms. It was shown that performing such a procedure in patients with ulcerative colitis caused the appearance of T helper cells in the blood, which reacted to the content of sterile stool filtrates in an antigen-specific manner and produced IL-10. At the same time, cells of the same patients before therapy in response to the addition of sterile stool filtrates were less reactive and predominantly produced IL-4, indicating its pro-inflammatory skewing. The obtained data demonstrated the effect of an anti-inflammatory shift in the T-helper response after transplantation of sterile stool filtrate, which increased and persisted for at least three months after the procedure.

Chechushkov A. , Desyukevich P. , Yakovlev T. , Al Allaf L. , Shrainer E. , Morozov V. , Tikunova N.
Sterile Fecal Microbiota Transplantation Boosts Anti-Inflammatory T-Cell Response in Ulcerative Colitis Patients
International Journal of Molecular Sciences. 2024. V.25. N3. 1886 . DOI: 10.3390/ijms25031886 WOS Scopus OpenAlex

Опубликована в печати:

4 февр. 2024 г.

Web of science:	WOS:001160121600001
Scopus:	2-s2.0-85184739918
OpenAlex:	W4391533444

БД	Цитирований
OpenAlex	2
Web of science	2
Scopus	1