Genetic Diversity of the Human Adenovirus C Isolated from Hospitalized Children in Russia (2019–2022)

Genetic Diversity of the Human Adenovirus C Isolated from Hospitalized Children in Russia (2019–2022) Научная публикация

Журнал

Viruses
ISSN: 1999-4915

Вых. Данные

Год: 2024, Том: 16, Номер: 3, Номер статьи : 386, Страниц : DOI: 10.3390/v16030386

Ключевые слова

human adenovirus; adenovirus typing; genotypes C1; C2; C5; C89; C108; molecular epidemiology; pediatric infections; respiratory virus

Авторы

Kurskaya Olga G. ¹ , Prokopyeva Elena A. ¹ , Dubovitskiy Nikita A. ¹ , Solomatina Mariya V. ¹ , Sobolev Ivan A. ¹ , Derko Anastasiya A. ¹ , Nokhova Alina R. ¹ , Anoshina Angelika V. ² , Leonova Natalya V. ² , Simkina Olga A. ³ , Komissarova Tatyana V. ³ , Tupikin Alexey E. ⁴ , Kabilov Marsel R. ⁴ , Shestopalov Alexander M. ¹ , Sharshov Kirill A. ¹

Организации

1	Laboratory of Molecular Epidemiology and Biodiversity of Viruses, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk 630060, Russia
2	Department of Children’s Diseases, Novosibirsk Children’s Municipal Clinical Hospital №6, Novosibirsk 630015, Russia
3	Department of Children’s Diseases, Novosibirsk Children’s Municipal Clinical Hospital №3, Novosibirsk 630040, Russia
4	Genomics Core Facility, Institute of Chemical Biology and Fundamental Medicine, Novosibirsk 630090, Russia

The human adenovirus (HAdV) is a common pathogen in children that can cause acute respiratory virus infection (ARVI). However, the molecular epidemiological and clinical information relating to HAdV among hospitalized children with ARVI is rarely reported in Russia. A 4-year longitudinal (2019–2022) study among hospitalized children (0–17 years old) with ARVI in Novosibirsk, Russia, was conducted to evaluate the epidemiological and molecular characteristics of HAdV. Statistically significant differences in the detection rates of epidemiological and virological data of all positive viral detections of HAdV were analyzed using a two-tailed Chi-square test. The incidence of HAdV and other respiratory viruses such as human influenza A and B viruses, respiratory syncytial virus, coronavirus, parainfluenza virus, metapneumovirus, rhinovirus, bocavirus, and SARS-CoV-2 was investigated among 3190 hospitalized children using real-time polymerase chain reaction. At least one of these respiratory viruses was detected in 74.4% of hospitalized cases, among which HAdV accounted for 4%. A total of 1.3% co-infections with HAdV were also registered. We obtained full-genome sequences of 12 HAdVs, which were isolated in cell cultures. Genetic analysis revealed the circulation of adenovirus of genotypes C1, C2, C5, C89, and 108 among hospitalized children in the period from 2019–2022.

Kurskaya O.G. , Prokopyeva E.A. , Dubovitskiy N.A. , Solomatina M.V. , Sobolev I.A. , Derko A.A. , Nokhova A.R. , Anoshina A.V. , Leonova N.V. , Simkina O.A. , Komissarova T.V. , Tupikin A.E. , Kabilov M.R. , Shestopalov A.M. , Sharshov K.A.
Genetic Diversity of the Human Adenovirus C Isolated from Hospitalized Children in Russia (2019–2022)
Viruses. 2024. V.16. N3. 386 . DOI: 10.3390/v16030386 WOS Scopus РИНЦ OpenAlex

Опубликована в печати:

29 февр. 2024 г.

≡ Web of science:	WOS:001192477900001
≡ Scopus:	2-s2.0-85188996518
≡ РИНЦ:	66258431
≡ OpenAlex:	W4392355756