Supramolecular Self-Associations of Amphiphilic Dendrons and Their Properties

Supramolecular Self-Associations of Amphiphilic Dendrons and Their Properties Full article

Journal

Chemistry - A European Journal
ISSN: 0947-6539

Output data

Year: 2021, Volume: 27, Number: 72, Pages: 17976-17998 Pages count : 23 DOI: 10.1002/chem.202102589

Tags

amphiphiles; dendrons; encapsulation; micelles; self-association

Authors

Apartsin Evgeny ^1,2,3,4 , Caminade Anne-Marie ^1,2

Affiliations

1	(Данные Web of science) CNRS, Lab Chim Coordinat LCC, 205 Route Narbonne, F-31077 Toulouse 4, France
2	(Данные Web of science) Univ Toulouse, CNRS, LCC CNRS, F-31077 Toulouse 4, France
3	(Данные Web of science) Inst Chem Biol & Fundamental Med, Novosibirsk 630090, Russia
4	(Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia

This review presents precisely defined amphiphilic dendrons, their self-association properties, and their different uses. Dendrons, also named dendritic wedges, are composed of a core having two different types of functions, of which one type is used for growing or grafting branched arms, generally multiplied by 2 at each layer by using 1 -> 2 branching motifs. A large diversity of structures has been already synthesized. In practically all cases, their synthesis is based on the synthesis of known dendrimers, such as poly(aryl ether), poly(amidoamine) (in particular PAMAM), poly(amide) (in particular poly(L-lysine)), 1 -> 3 branching motifs (instead of 1 -> 2), poly(alkyl ether) (poly(glycerol) and poly(ethylene glycol)), poly(ester), and those containing main group elements (poly(carbosilane) and poly(phosphorhydrazone)). In most cases, the hydrophilic functions are on the surface of the dendrons, whereas one or two hydrophobic tails are linked to the core. Depending on the structure of the dendrons, and on the experimental conditions used, the amphiphilic dendrons can self-associate at the air-water interface, or form micelles (eventually tubular, but most generally spherical), or form vesicles. These associated dendrons are suitable for the encapsulation of low-molecular or macromolecular bioactive entities to be delivered in cells. This review is organized depending on the nature of the internal structure of the amphiphilic dendrons (aryl ether, amidoamine, amide, quaternary carbon atom, alkyl ether, ester, main group element). The properties issued from their self-associations are described all along the review.

Apartsin E. , Caminade A-M.
Supramolecular Self-Associations of Amphiphilic Dendrons and Their Properties
Chemistry - A European Journal. 2021. V.27. N72. P.17976-17998. DOI: 10.1002/chem.202102589 WOS Scopus РИНЦ OpenAlex

Published print:

Oct 29, 2021

Web of science:	WOS:000712250000001
Scopus:	2-s2.0-85118200079
Elibrary:	47518845
OpenAlex:	W3209412677

DB	Citing
Web of science	28
Elibrary	24
Scopus	21
OpenAlex	29