Aberrant repair of 8-oxoguanine in short DNA bulges

Aberrant repair of 8-oxoguanine in short DNA bulges Full article

Journal

ДОКЛАДЫ РОССИЙСКОЙ АКАДЕМИИ НАУК. НАУКИ О ЖИЗНИ
ISSN: 2686-7389

Output data

Year: 2024, Volume: 515, Number: 2, Pages: 14-18 Pages count : 5 DOI: 10.31857/s2686738924020031

Tags

DNA damage, mutagenesis, DNA repair, DNA glycosylases, 8-oxoguanine, Fpg, OGG1

Authors

Eroshenko D.A. ^1,2 , Diatlova E.A. ¹ , Golyshev V.M. ¹ , Endutkin A.V. ¹ , Zharkov D.O. ^1,2

Affiliations

1	Institute of Chemical Biology and Fundamental Medicine SB RAS
2	Novosibirsk State University

The presence of DNA damage can increase the likelihood of DNA replication errors and promote mutations. In particular, pauses of DNA polymerase at the site of damage can lead to polymerase slippage and the formation of 1–2-nucleotide bulges. Repair of such structures using an undamaged DNA template leads to small deletions. One of the most abundant oxidative DNA lesions, 8-oxoguanine (oxoG), was shown to induce small deletions, but the mechanism of this phenomenon is currently unknown. We studied the aberrant repair of oxoG located in one- and two-nucleotide bulges by the Escherichia coli and human base excision repair systems. Our results indicate that the repair in such substrates can serve as a mechanism for fixing small deletions in bacteria but not in humans

Eroshenko D.A. , Diatlova E.A. , Golyshev V.M. , Endutkin A.V. , Zharkov D.O.
Aberrant repair of 8-oxoguanine in short DNA bulges
ДОКЛАДЫ РОССИЙСКОЙ АКАДЕМИИ НАУК. НАУКИ О ЖИЗНИ. 2024. V.515. N2. P.14-18. DOI: 10.31857/s2686738924020031 OpenAlex

Ерошенко Д.А. , Дятлова Е.А. , Голышев В.М. , Ендуткин А.В. , Жарков Д.О.
Аберрантная репарация 8-оксогуанина в коротких выпетливаниях ДНК
Doklady Biochemistry and Biophysics. 2024. Т.515. №2. С.14–18.

OpenAlex:

W4402106311

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