Structural and Molecular Kinetic Features of Activities of DNA Polymerases Full article
| Journal |
International Journal of Molecular Sciences
, E-ISSN: 1422-0067 |
||||
|---|---|---|---|---|---|
| Output data | Year: 2022, Volume: 23, Number: 12, Article number : 6373, Pages count : DOI: 10.3390/ijms23126373 | ||||
| Tags | catalytic mechanism; DNA polymerase; kinetics; protein–DNA interaction; structural family | ||||
| Authors |
|
||||
| Affiliations |
|
Abstract:
DNA polymerases catalyze DNA synthesis during the replication, repair, and recombination of DNA. Based on phylogenetic analysis and primary protein sequences, DNA polymerases have been categorized into seven families: A, B, C, D, X, Y, and RT. This review presents generalized data on the catalytic mechanism of action of DNA polymerases. The structural features of different DNA polymerase families are described in detail. The discussion highlights the kinetics and conformational dynamics of DNA polymerases from all known polymerase families during DNA synthesis. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Cite:
Kuznetsova A.A.
, Fedorova O.S.
, Kuznetsov N.A.
Structural and Molecular Kinetic Features of Activities of DNA Polymerases
International Journal of Molecular Sciences. 2022. V.23. N12. 6373 . DOI: 10.3390/ijms23126373 WOS Scopus РИНЦ OpenAlex
Structural and Molecular Kinetic Features of Activities of DNA Polymerases
International Journal of Molecular Sciences. 2022. V.23. N12. 6373 . DOI: 10.3390/ijms23126373 WOS Scopus РИНЦ OpenAlex
Dates:
| Published print: | Jun 7, 2022 |
Identifiers:
| Web of science: | WOS:000818193000001 |
| Scopus: | 2-s2.0-85131315396 |
| Elibrary: | 48718087 |
| OpenAlex: | W4281671069 |