Designing pH-dependent systems based on nanoscale calcium carbonate for the delivery of an antitumor drug

Designing pH-dependent systems based on nanoscale calcium carbonate for the delivery of an antitumor drug Full article

Journal

Nanomaterials
ISSN: 2079-4991

Output data

Year: 2021, Volume: 11, Number: 11, Article number : 2794, Pages count : DOI: 10.3390/nano11112794

Tags

Calcium carbonate nanoparticle; DOXorubicin; Prolonged release

Authors

Popova V. ¹ , Poletaeva Y. ¹ , Pyshnaya I. ¹ , Pyshnyi D. ¹ , Dmitrienko E. ¹

Affiliations

1	Institute of Chemical Biology and Fundamental Medicine (ICBFM), Siberian Branch of Russian Academy of Sciences (SB RAS), 8 Lavrentiev Avenue, Novosibirsk, 630090, Russian Federation

Materials based on calcium carbonate (CaCO3) are widely used in biomedical research (e.g., as carriers of bioactive substances). The biocompatibility of CaCO3 and dependence of its stability on pH make these materials promising transporters of therapeutic agents to sites with low pH such as a tumor tissue. In this work, we developed an approach to the preparation of nanoscale particles based on CaCO3 (CaNPs) up to 200 nm in size by coprecipitation and analyzed the interaction of the nanoparticles with an anticancer drug: DOXorubicin (DOX). We also showed a prolonged pH-dependent release of DOX from a CaNP nanocarrier and effective inhibition of cancer cell growth by a CaCO3-and-DOX–based composite (CaNP7-DOX) in in vitro models. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Popova V. , Poletaeva Y. , Pyshnaya I. , Pyshnyi D. , Dmitrienko E.
Designing pH-dependent systems based on nanoscale calcium carbonate for the delivery of an antitumor drug
Nanomaterials. 2021. V.11. N11. 2794 . DOI: 10.3390/nano11112794 WOS Scopus РИНЦ OpenAlex

Published print:

Oct 21, 2021

Web of science:	WOS:000723908300001
Scopus:	2-s2.0-85117384934
Elibrary:	47514770
OpenAlex:	W3205301911

DB	Citing
Scopus	21
Web of science	28
OpenAlex	34