Recent Advances in the Synthesis of High Boron-Loaded Nucleic Acids for BNCT Full article
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Frontiers in Chemistry
ISSN: 2296-2646 |
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| Output data | Year: 2021, Volume: 9, Article number : 619052, Pages count : DOI: 10.3389/fchem.2021.619052 | ||
| Tags | BNCT; boron cluster; boron neutron capture therapy; conjugation method; oligonucleotide conjugate; pre- and post-synthetic modification | ||
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Abstract:
Boron clusters attract considerable attention as promising therapeutic tools for boron neutron capture therapy (BNCT). They combine high boron content with high chemical and biological stability, biorthogonality, and low toxicity. The development of oligonucleotide-based constructs and nucleic acid-like molecules, such as oligomeric phosphate diesters, bearing one or multiple boron clusters permits to create potential high boron-loaded agents for BNCT with good bioavailability, specifically interacting with nucleic acids inside the cell. Here, we shortly review the strategies and solutions in the design of oligonucleotide conjugates with boron clusters in light of the requirements for effective BNCT and future prospects of their practical use. © Copyright © 2021 Novopashina, Vorobyeva and Venyaminova.
Cite:
Novopashina D.S.
, Vorobyeva M.A.
, Venyaminova A.
Recent Advances in the Synthesis of High Boron-Loaded Nucleic Acids for BNCT
Frontiers in Chemistry. 2021. V.9. 619052 . DOI: 10.3389/fchem.2021.619052 WOS Scopus РИНЦ OpenAlex
Recent Advances in the Synthesis of High Boron-Loaded Nucleic Acids for BNCT
Frontiers in Chemistry. 2021. V.9. 619052 . DOI: 10.3389/fchem.2021.619052 WOS Scopus РИНЦ OpenAlex
Dates:
| Published print: | Mar 15, 2021 |
Identifiers:
| Web of science: | WOS:000634263900001 |
| Scopus: | 2-s2.0-85103327930 |
| Elibrary: | 46771443 |
| OpenAlex: | W3136883683 |