Initial stages of DNA Base Excision Repair in Nucleosomes Full article
| Journal |
Molecular Biology
ISSN: 0026-8933 |
||
|---|---|---|---|
| Output data | Year: 2021, Volume: 55, Number: 2, Pages: 167-181 Pages count : 15 DOI: 10.1134/S0026893321020096 | ||
| Tags | AP-endonuclease; DNA repair; DNA-glycosylase; nucleosome | ||
| Authors |
|
||
| Affiliations |
|
Abstract:
Abstract: In mammalian cells, base excision repair (BER) is the main pathway responsible for the correction of a variety of chemically modified DNA bases. DNA packaging in chromatin affects the accessibility of damaged sites to the enzymes involved in repair processes. This review presents data concerning the enzymes involved in BER. Within the nucleosome core particle (NCP), the accessibility of damaged DNA to enzymes is hindered by the presence of a histone octamer. This means that the removal of DNA lesions largely depends on their rotational and translational positioning in the NCP, as well as on the specific features of each enzyme. © 2021, Pleiades Publishing, Inc.
Cite:
Kladova O.A.
, Kuznetsov N.A.
, Fedorova O.S.
Initial stages of DNA Base Excision Repair in Nucleosomes
Molecular Biology. 2021. V.55. N2. P.167-181. DOI: 10.1134/S0026893321020096 WOS Scopus РИНЦ OpenAlex
Initial stages of DNA Base Excision Repair in Nucleosomes
Molecular Biology. 2021. V.55. N2. P.167-181. DOI: 10.1134/S0026893321020096 WOS Scopus РИНЦ OpenAlex
Original:
Кладова О.А.
, Кузнецов Н.А.
, Федорова О.С.
Начальные стадии эксцизионной репарации оснований ДНК в нуклеосомах
Молекулярная биология. 2021. Т.55. №2. С.194-209. DOI: 10.31857/S0026898421020087 Scopus РИНЦ OpenAlex
Начальные стадии эксцизионной репарации оснований ДНК в нуклеосомах
Молекулярная биология. 2021. Т.55. №2. С.194-209. DOI: 10.31857/S0026898421020087 Scopus РИНЦ OpenAlex
Identifiers:
| Web of science: | WOS:000646053000002 |
| Scopus: | 2-s2.0-85104980516 |
| Elibrary: | 46038877 |
| OpenAlex: | W4210997625 |