Dataset for dynamics and conformational changes in human NEIL2 protein analyzed by integrative structural biology approach Full article
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Data in Brief
ISSN: 2352-3409 |
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| Output data | Year: 2022, Volume: 40, Article number : 107760, Pages count : DOI: 10.1016/j.dib.2021.107760 | ||||||||
| Tags | Base excision repair; DNA damage; DNA glycosylases; DNA repair; HDX-MS; Molecular dynamics; NEIL2; Structural dynamics | ||||||||
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Abstract:
This work presents new data on human endonuclease VIII-like 2 protein (hNEIL2), a part of DNA glycosylases of the helix–two-turn–helix structural superfamily. While X-ray structure of oNEIL2 (opossum Monodelphis) was resolved partially [1], the structure of hNEIL2 has not yet been determined. This data article describes a powerful combination of hydrogen-deuterium exchange mass spectrometry, homology modeling, and molecular dynamics simulations for protein conformational dynamics analysis. The data supplied in this work are related to the research article entitled “Dynamics and Conformational Changes in Human NEIL2 DNA Glycosylase Analyzed by Hydrogen/Deuterium Exchange Mass Spectrometry”. © 2021
Cite:
Zhdanova P.V.
, Ishchenko A.A.
, Chernonosov A.A.
, Zharkov D.O.
, Koval V.V.
Dataset for dynamics and conformational changes in human NEIL2 protein analyzed by integrative structural biology approach
Data in Brief. 2022. V.40. 107760 . DOI: 10.1016/j.dib.2021.107760 WOS Scopus РИНЦ OpenAlex
Dataset for dynamics and conformational changes in human NEIL2 protein analyzed by integrative structural biology approach
Data in Brief. 2022. V.40. 107760 . DOI: 10.1016/j.dib.2021.107760 WOS Scopus РИНЦ OpenAlex
Dates:
| Published online: | Jan 30, 2022 |
Identifiers:
| Web of science: | WOS:000780046700016 |
| Scopus: | 2-s2.0-85121788925 |
| Elibrary: | 47550702 |
| OpenAlex: | W4200459250 |