Magnetoactive electrospun hybrid scaffolds based on poly(vinylidene fluoride-co-trifluoroethylene) and magnetite particles with varied sizes

Magnetoactive electrospun hybrid scaffolds based on poly(vinylidene fluoride-co-trifluoroethylene) and magnetite particles with varied sizes Full article

Journal

Polymer Engineering and Science

Output data

Year: 2022, Volume: 62, Number: 5, Pages: 1593-1607 Pages count : 15 DOI: 10.1002/pen.25947

Tags

composites; electrospinning; fluoropolymers; magnetite; scaffold

Authors

Botvin V.V. ^1,2 , Surmeneva M.A. ^1,3 , Mukhortova Y.R. ^1,3 , Belyakova E.O. ¹ , Wagner D.V. ⁴ , Chelobanov B.P. ^5,6 , Laktionov P.P. ⁵ , Sukhinina E.V. ^7,8 , Pershina A.G. ^7,8 , Kholkin A.L. ^1,9 , Surmenev R.A. ^1,3

Affiliations

1	International Research & Development Center “Piezo- and magnetoelectric materials”, Research School of Chemistry & Applied Biomedical Sciences, National Research Tomsk Polytechnic University, Tomsk, Russian Federation
2	Department of High Molecular Compounds and Petrochemistry, Faculty of Chemistry, National Research Tomsk State University, Tomsk, Russian Federation
3	Physical Materials Science and Composite Materials Centre, Research School of Chemistry & Applied Biomedical Sciences, National Research Tomsk Polytechnic University, Tomsk, Russian Federation
4	Scientific Laboratory for Terahertz Research, National Research Tomsk State University, Tomsk, Russian Federation
5	Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russian Federation
6	Section of Molecular Biology and Biotechnology, Department of Natural Sciences, Novosibirsk State University, Novosibirsk, Russian Federation
7	Research School of Chemistry & Applied Biomedical Sciences, National Research Tomsk Polytechnic University, Tomsk, Russian Federation
8	Center of Bioscience & Bioengineering, Siberian State Medical University, Tomsk, Russian Federation
9	Department of Physics & CICECO – Aveiro Institute of Materials, University of Aveiro, Aveiro, Portugal

The development of functional magnetoactive materials fabricated in the form of electrospun scaffolds is of paramount importance for modern medicine and pharmaceuticals. To precisely control the morphology and magnetic properties of the composite magnetoactive scaffolds, the electrospinning conditions, incorporation method of magnetic particles into the polymer solution to avoid agglomeration, and the shape/size of the particles should be thoroughly studied. In this study, hybrid magnetoactive scaffolds based on poly(vinylidene fluoride-co-trifluoroethylene) (P(VDF-TrFE)), doped with either unmodified magnetite (Fe3O4) or magnetite particles modified with oleic acid (Fe3O4/OA), have been fabricated by electrospinning. Modification of magnetite particles by oleic acid results in the formation of nanosized particles in comparison with submicron-sized Fe3O4 particles (37 vs. 329 nm), which reveal a greater affinity to P(VDF-TrFE) due to their hydrophobic surface. Composite scaffolds prepared using 30 wt% polymer solution with 8 wt% Fe3O4 and Fe3O4/OA reveal saturation magnetization values of 9.14 and 5.8 emu/g, respectively. The saturation magnetization of composite scaffolds agrees well with the saturation magnetization of the initial magnetites. Considering the better dispersion of Fe3O4/OA in the polymer solution, a series of composite scaffolds with 4 and 12 wt% concentrations of magnetite have been studied. Cytotoxicity tests demonstrated that all the fabricated composite scaffolds are nontoxic to human cells. Variation of magnetite particles content in the polymer fibers enables to obtain composite scaffolds with tailored saturation magnetization, which can be potentially used as perspective magnetoactive and magnetoelectric materials for biomedical application. © 2022 Society of Plastics Engineers.

Botvin V.V. , Surmeneva M.A. , Mukhortova Y.R. , Belyakova E.O. , Wagner D.V. , Chelobanov B.P. , Laktionov P.P. , Sukhinina E.V. , Pershina A.G. , Kholkin A.L. , Surmenev R.A.
Magnetoactive electrospun hybrid scaffolds based on poly(vinylidene fluoride-co-trifluoroethylene) and magnetite particles with varied sizes
Polymer Engineering and Science. 2022. V.62. N5. P.1593-1607. DOI: 10.1002/pen.25947 WOS Scopus OpenAlex

Published print:

Mar 3, 2022

Web of science:	WOS:000763487300001
Scopus:	2-s2.0-85125521897
OpenAlex:	W4214861630

DB	Citing
Scopus	8
Web of science	10
OpenAlex	12