Levels of Acylcarnitines and Branched-Chain Amino Acids in Antipsychotic-Treated Patients with Paranoid Schizophrenia with Metabolic Syndrome

Levels of Acylcarnitines and Branched-Chain Amino Acids in Antipsychotic-Treated Patients with Paranoid Schizophrenia with Metabolic Syndrome Full article

Journal

Metabolites
ISSN: 2218-1989

Output data

Year: 2022, Volume: 12, Number: 9, Article number : 850, Pages count : DOI: 10.3390/metabo12090850

Tags

acylcarnitine; amino acid; metabolic syndrome; metabolomics; schizophrenia

Authors

Mednova I.A. ¹ , Chernonosov A.A. ² , Kornetova E.G. ^1,3 , Semke A.V. ¹ , Bokhan N.A. ^1,4 , Koval V.V. ² , Ivanova S.A. ^1,4

Affiliations

1	Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Aleutskaya Str. 4, Tomsk, 634014, Russian Federation
2	Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, Lavrentyev Avenue 8, Novosibirsk, 630090, Russian Federation
3	Siberian State Medical University Hospital, Moskovsky Trakt 2, Tomsk, 634050, Russian Federation
4	Department of Psychiatry, Addictology and Psychotherapy, Siberian State Medical University, Moskovsky Trakt 2, Tomsk, 634050, Russian Federation

Several studies have shown that patients with schizophrenia are at high risk for metabolic syndrome (MetS) and bioenergetic dysfunction. Because acylcarnitines are involved in bioenergetic pathways and reflect the functioning of mitochondria, we hypothesized that these compounds are biomarkers of MetS in schizophrenia. The aim of this work was to quantify acylcarnitines and branched-chain amino acids in patients with schizophrenia comorbid with MetS. The study included 112 patients with paranoid schizophrenia treated with antipsychotics. Among them, 39 subjects met criteria of MetS. Concentrations of 30 acylcarnitines and three amino acids in dry serum spots were measured by liquid chromatography coupled with tandem mass spectrometry. MetS patients were found to have higher levels of valeryl carnitine (C5), leucine/isoleucine, and alanine as compared with patients without MetS, indicating possible participation of these compounds in the pathogenesis of metabolic disorders in schizophrenia. In patients with paranoid schizophrenia with or without MetS, lower levels of carnitines C10, C10:1, C12, and C18 were recorded as compared with the healthy individuals (n = 70), implying deterioration of energy metabolism. We believe that this finding can be explained by effects of antipsychotic medication on an enzyme called carnitine-palmitoyl transferase I. © 2022 by the authors.

Mednova I.A. , Chernonosov A.A. , Kornetova E.G. , Semke A.V. , Bokhan N.A. , Koval V.V. , Ivanova S.A.
Levels of Acylcarnitines and Branched-Chain Amino Acids in Antipsychotic-Treated Patients with Paranoid Schizophrenia with Metabolic Syndrome
Metabolites. 2022. V.12. N9. 850 . DOI: 10.3390/metabo12090850 WOS Scopus РИНЦ OpenAlex

Web of science:	WOS:000858879400001
Scopus:	2-s2.0-85138642619
Elibrary:	56611616
OpenAlex:	W4296004805

DB	Citing
Scopus	3
Web of science	4
OpenAlex	8