Oligonucleotide aptamers as novel cell-specific delivery agents for boron neutron capture therapy

Oligonucleotide aptamers as novel cell-specific delivery agents for boron neutron capture therapy Full article

Journal

Siberian Medical Review

Output data

Year: 2022, Volume: 2022, Number: 5, Article number : 108, Pages count : DOI: 10.20333/25000136-2022-5-108

Tags

CELL-SPECIFIC APTAMERS, HUMAN GLIOBLASTOMA CELLS, BORON CLUSTERS, BORON NEUTRON CAPTURE THERAPY, CANCER TREATMENT, DRUG DELIVERY

Authors

Vorobyeva M.A. ¹ , Dymova M.A. ¹ , Novopashina D.S. ¹ , Kuligina E.V. ¹ , Kolesnikov I.A. ^1,2 , Taskaev S.Y. ² , Richter V.A. ¹ , Meschaninova M.I. ¹

Affiliations

1	Institute of Chemical Biology and Fundamental Medicine SB RAS
2	Budker Institute of Nuclear Physics, SB RAS

Oligonucleotide aptamers seem to be promising delivery vehicles addressing boron compounds to tumour cells for boron neutron capture therapy (BNCT). Here, we report the first example of using 2'-F-RNA aptamer specific to human glioblastoma cells as a delivery agent for boron clusters, which provides cell internalisation sufficient for the BNCT model.

Vorobyeva M.A. , Dymova M.A. , Novopashina D.S. , Kuligina E.V. , Kolesnikov I.A. , Taskaev S.Y. , Richter V.A. , Meschaninova M.I.
Oligonucleotide aptamers as novel cell-specific delivery agents for boron neutron capture therapy
Siberian Medical Review. 2022. V.2022. N5. 108 . DOI: 10.20333/25000136-2022-5-108 Scopus РИНЦ OpenAlex

Submitted:

Aug 18, 2022

Scopus:	2-s2.0-85141496161
Elibrary:	49747939
OpenAlex:	W4313124340

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