FEASIBILITY OF DELIVERY IN PATIENTS RECEIVING MESENCHYMAL STROMAL CELL-DERIVED EXTRACELLULAR MICROVESICLES DURING THE PREVIOUS CAESAREAN SECTION (Возможности родоразрешения пациенток, которым в ходе предшествующего кесарева сечения вводились экстрацеллюлярные микровезикулы мезенхимальных стромальных клеток)

FEASIBILITY OF DELIVERY IN PATIENTS RECEIVING MESENCHYMAL STROMAL CELL-DERIVED EXTRACELLULAR MICROVESICLES DURING THE PREVIOUS CAESAREAN SECTION (Возможности родоразрешения пациенток, которым в ходе предшествующего кесарева сечения вводились экстрацеллюлярные микровезикулы мезенхимальных стромальных клеток) Full article

Journal

Akusherstvo i Ginekologiya (Russian Federation)
ISSN: 0300-9092

Output data

Year: 2022, Volume: 2022, Number: 4, Pages: 103-114 Pages count : 12 DOI: 10.18565/aig.2022.4.103-114

Tags

abdominal delivery; exosomes; extracellular microvesicles; spontaneous delivery; uterine scar

Authors

Sukhikh G.T. ¹ , Pekareva E.O. ² , Pekarev O.G. ¹ , Silachev D.N. ¹ , Maiborodin I.V. ³ , Baranov I.I. ¹ , Pozdnyakov I.M. ² , Bushueva N.S. ²

Affiliations

1	Academician of the RAS, Director of the V.I. Kulakov NMRC for OG&P, Ministry of Health of Russia, 4, Oparina str., Moscow, 117997, Russian Federation
2	Researcher of the Stem Cell Laboratory, Institute of Chemical Biology and Fundamental Medicine, SB of the RAS, 8, Ac. Lavrentyeva str., Novosibirsk, 630090, Russian Federation
3	Novosibirsk City Clinical Perinatal Center, 32, Lezhena str., Novosibirsk, 630090, Russian Federation

Objective: To investigate the postoperative course of patients receiving exosome – extracellular microvesicles (EMV) of mesenchymal stromal cells (MSC) during a previous cesarean section and the results of subsequent delivery. Materials and methods: The study group included 60 women who received 500 µl of MSC EMV. The control group consisted of 100 patients without exosomal support. At the stage of delivery, patients were further divided into subgroup a (spontaneous delivery) and b (repeat cesarean section). Results: The study group had no septic complications, while in the control group 6% and 2% of the patients developed postpartum endometritis and lochimetra, respectively. In the study group, 5/8 (62.5%) patients had spontaneous labor, while in the control group 16/20 (80%) women underwent a repeat cesarean section. Nineteen biopsy specimens from the dissected scars were submitted for pathomorphological examination. Conclusion: Intraoperative injection of EMV was highly effective in complete scar formation compared to the control group. In 5/8 (62.5%) patients with exosomal support resulted in spontaneous delivery; in the control group, this figure was 4/20 (20%). The study showed the feasibility of using MSC EMV to reduce abdominal delivery rate in patients with post-cesarean uterine scar. © A group of authors, 2022.

Sukhikh G.T. , Pekareva E.O. , Pekarev O.G. , Silachev D.N. , Maiborodin I.V. , Baranov I.I. , Pozdnyakov I.M. , Bushueva N.S.
FEASIBILITY OF DELIVERY IN PATIENTS RECEIVING MESENCHYMAL STROMAL CELL-DERIVED EXTRACELLULAR MICROVESICLES DURING THE PREVIOUS CAESAREAN SECTION (Возможности родоразрешения пациенток, которым в ходе предшествующего кесарева сечения вводились экстрацеллюлярные микровезикулы мезенхимальных стромальных клеток)
Akusherstvo i Ginekologiya (Russian Federation). 2022. V.2022. N4. P.103-114. DOI: 10.18565/aig.2022.4.103-114 Scopus РИНЦ OpenAlex

Submitted:

Feb 24, 2022

Scopus:	2-s2.0-85129584477
Elibrary:	48333286
OpenAlex:	W4280514189

DB	Citing
Scopus	1
Elibrary	5
OpenAlex	1