Non-Targeted Screening of Metabolites in Aqueous-Ethanol Extract from Spiraea hypericifolia (Rosaceae) Using LC-HRMS Научная публикация
| Журнал |
International Journal of Molecular Sciences
, E-ISSN: 1422-0067 |
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| Вых. Данные | Год: 2023, Том: 24, Номер статьи : 13872, Страниц : 15 DOI: 10.3390/ijms241813872 | ||||||
| Ключевые слова | Spiraea hypericifolia; LC-HRMS; HPLC; metabolome; flavonoid; antioxidant activity | ||||||
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Реферат:
By means of liquid chromatography combined with high-resolution mass spectrometry, metabolite profiling was performed on an aqueous-ethanol extract from Spiraea hypericifolia (Rosaceae) collected in Siberia (Russia). Up to 140 compounds were found in the extract, of which 47 were tentatively identified. The identified compounds were amino acids, sugars, phenylpropanoids, fatty acids and their derivatives, triterpenoids, flavonoids, and others. A quantitative analysis showed the predominance of phenolcarboxylic acids and flavonoids in the studied extract, but a qualitative analysis revealed the higher structural diversity of flavonoids. Of the 23 identified flavonoids, 13 were flavonols: quercetin, hyperoside, isoquercitrin, reynoutrin, avicularin, rutin, quercetin-3-O-(6″-O-malonyl)-β-D-glucoside, 3-O-methylquercetin-3′-O-β-D-glucopyranoside, isorhamnetin, rhamnetin-3-O-β-D-xylopyranosyl-β-D-glucopyranoside, kaempferol, tiliroside, and trifolin; six were catechins: catechin, (−)-epicatechin, (+)-epicatechin, (+)-catechin-7-O-β-D-xyloside, (2S,3R)-3,5-dihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-7-yl-β-D-glucopyranoside, and catechin 7-O-apiofuranoside; two are isoflavones: genistin and genistein; and one was a flavone (luteolin-4′-O-β-D-glucopyranoside) and another was an anthocyanidin (pelargonidin). The aqueous-ethanol extract from S. hypericifolia showed antioxidant activity (half-maximal inhibitory concentration 102.95 μg/mL), which was likely related to the high concentrations of phenolcarboxylic acids (229.6 mg/g), flavonoids (118.3 mg/g), and tannins (62.9 mg/g).
Библиографическая ссылка:
Kostikova V.A.
, Petrova N.V.
, Shaldaeva T.M.
, Koval V.V.
, Chernonosov A.A.
Non-Targeted Screening of Metabolites in Aqueous-Ethanol Extract from Spiraea hypericifolia (Rosaceae) Using LC-HRMS
International Journal of Molecular Sciences. 2023. V.24. 13872 :1-15. DOI: 10.3390/ijms241813872 WOS Scopus OpenAlex
Non-Targeted Screening of Metabolites in Aqueous-Ethanol Extract from Spiraea hypericifolia (Rosaceae) Using LC-HRMS
International Journal of Molecular Sciences. 2023. V.24. 13872 :1-15. DOI: 10.3390/ijms241813872 WOS Scopus OpenAlex
Даты:
| Опубликована в печати: | 4 сент. 2023 г. |
Идентификаторы БД:
| Web of science: | WOS:001073770900001 |
| Scopus: | 2-s2.0-85172810395 |
| OpenAlex: | W4386602541 |