Possible Kidney Complications after Application of Cell Technologies for the Repair of the Resected Liver

Possible Kidney Complications after Application of Cell Technologies for the Repair of the Resected Liver Научная публикация

Журнал

Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888

Вых. Данные

Год: 2023, Том: 175, Номер: 1, Страницы: 138-143 Страниц : 6 DOI: 10.1007/s10517-023-05825-y

Ключевые слова

liver; partial resection; multipotent stromal cells; kidneys; fuorescence microscopy

Авторы

Maiborodin I.V. ^1,2 , Maslov R.V. ² , Marchukov S.V. ² , Klochkova S.V. ³ , Sheplev B.V. ² , Maiborodina V.I. ² , Ryaguzov M.E. ¹ , Lushnikova E.L. ²

Организации

1	Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia
2	Institute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia
3	Department of Human Anatomy, Institute of Medicine, Peoples’ Friendship University of Russia (RUDN University), Moscow, Russia

The state of rat kidneys after injection of bone marrow multipotent stromal cells (MSC) labeled with Vybrant CM-Dil into intact or resected liver was studied by fuorescence microscopy. The main structural changes in the kidneys after MSC injection into intact and partially resected liver manifested as granular dystrophy and necrobiotic/necrotic changes in single epithelial cells of the distal tubules and collecting ducts, thrombosis of some vessels, progression of an ascending urinary tract infection (detection of dust-like fuorescent objects), which can be due to the immunomodulating or even immunosuppressive infuence of MSC and their detritus. MSC injected into the intact or resected liver, as well as the products of their degradation were not detected in the kidneys at all terms of observation. After injection of MSC into partially resected liver, manifestations of bacterial contamination of the renal medulla appeared later. The injection of MSC into the liver can be complicated by thrombosis of the renal vessels, which should be taken into account when using this administration route in the cell therapy.

Maiborodin I.V. , Maslov R.V. , Marchukov S.V. , Klochkova S.V. , Sheplev B.V. , Maiborodina V.I. , Ryaguzov M.E. , Lushnikova E.L.
Possible Kidney Complications after Application of Cell Technologies for the Repair of the Resected Liver
Bulletin of Experimental Biology and Medicine. 2023. V.175. N1. P.138-143. DOI: 10.1007/s10517-023-05825-y WOS Scopus РИНЦ PMID OpenAlex

Майбородин И.В. , Маслов Р.В. , Марчуков С.В. , Клочкова С.В. , Шеплев Б.В. , Майбородина В.И. , Рягузов М.Е. , Лушникова Е.Л.
Возможные осложнения со стороны почек после применения клеточных технологий для репарации резецированной печени
Клеточные технологии в биологии и медицине. 2023. №1. С.27-33. DOI: 10.47056/1814-3490-2023-27-33 РИНЦ

Опубликована в печати:

17 нояб. 2022 г.

Web of science:	WOS:001014983700001
Scopus:	2-s2.0-85162210394
РИНЦ:	59427700
PMID (PubMed):	37336807
OpenAlex:	W4381190267

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