Possible Kidney Complications after Application of Cell Technologies for the Repair of the Resected Liver Full article
Journal |
Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888 |
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Output data | Year: 2023, Volume: 175, Number: 1, Pages: 138-143 Pages count : 6 DOI: 10.1007/s10517-023-05825-y | ||||||
Tags | liver; partial resection; multipotent stromal cells; kidneys; fuorescence microscopy | ||||||
Authors |
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Abstract:
The state of rat kidneys after injection of bone marrow multipotent stromal cells (MSC)
labeled with Vybrant CM-Dil into intact or resected liver was studied by fuorescence microscopy. The main structural changes in the kidneys after MSC injection into intact and
partially resected liver manifested as granular dystrophy and necrobiotic/necrotic changes in
single epithelial cells of the distal tubules and collecting ducts, thrombosis of some vessels,
progression of an ascending urinary tract infection (detection of dust-like fuorescent objects),
which can be due to the immunomodulating or even immunosuppressive infuence of MSC
and their detritus. MSC injected into the intact or resected liver, as well as the products of
their degradation were not detected in the kidneys at all terms of observation. After injection
of MSC into partially resected liver, manifestations of bacterial contamination of the renal
medulla appeared later. The injection of MSC into the liver can be complicated by thrombosis of the renal vessels, which should be taken into account when using this administration
route in the cell therapy.
Cite:
Maiborodin I.V.
, Maslov R.V.
, Marchukov S.V.
, Klochkova S.V.
, Sheplev B.V.
, Maiborodina V.I.
, Ryaguzov M.E.
, Lushnikova E.L.
Possible Kidney Complications after Application of Cell Technologies for the Repair of the Resected Liver
Bulletin of Experimental Biology and Medicine. 2023. V.175. N1. P.138-143. DOI: 10.1007/s10517-023-05825-y WOS Scopus РИНЦ PMID OpenAlex
Possible Kidney Complications after Application of Cell Technologies for the Repair of the Resected Liver
Bulletin of Experimental Biology and Medicine. 2023. V.175. N1. P.138-143. DOI: 10.1007/s10517-023-05825-y WOS Scopus РИНЦ PMID OpenAlex
Original:
Майбородин И.В.
, Маслов Р.В.
, Марчуков С.В.
, Клочкова С.В.
, Шеплев Б.В.
, Майбородина В.И.
, Рягузов М.Е.
, Лушникова Е.Л.
Возможные осложнения со стороны почек после применения клеточных технологий для репарации резецированной печени
Клеточные технологии в биологии и медицине. 2023. №1. С.27-33. DOI: 10.47056/1814-3490-2023-27-33 РИНЦ
Возможные осложнения со стороны почек после применения клеточных технологий для репарации резецированной печени
Клеточные технологии в биологии и медицине. 2023. №1. С.27-33. DOI: 10.47056/1814-3490-2023-27-33 РИНЦ
Dates:
Published print: | Nov 17, 2022 |
Identifiers:
Web of science: | WOS:001014983700001 |
Scopus: | 2-s2.0-85162210394 |
Elibrary: | 59427700 |
PMID: | 37336807 |
OpenAlex: | W4381190267 |
Citing:
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