Structure of an Ice-Binding Protein from Myoxocephalus octodecemspinosus Determined by Molecular Dynamics and Based on Circular Dichroism Spectra

Structure of an Ice-Binding Protein from Myoxocephalus octodecemspinosus Determined by Molecular Dynamics and Based on Circular Dichroism Spectra Full article

Journal

Biophysics
ISSN: 0006-3509

Output data

Year: 2023, Volume: 68, Number: 4, Pages: 513-518 Pages count : 6 DOI: 10.1134/s0006350923040152

Tags

ice-binding proteins, antifreeze proteins, molecular dynamics, circular dichroism, cryoprotectants

Authors

Oleinik G.A. ¹ , Zhdanova P. ¹ , Koval V.V. ^1,2 , Chernonosov A.A. ¹ , Baranova S.V. ¹

Affiliations

1	Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia
2	Novosibirsk State University, Novosibirsk, Russia

—The production of proteins capable of binding ice is one of the strategies evolved in biological organisms for survival in cold ecosystems where there is a risk of freezing. These proteins have an important ability to bind to the surface of ice, influence its growth and prevent cell damage and death. To understand the nature of interaction of such proteins with ice, it is necessary to know their structure. This study contributes to the understanding of the structural and dynamic mechanisms of action of ice-binding proteins that ensure the adaptation of organisms in critical conditions. The study of the contribution of proteins capable of binding ice to adaptation to cold conditions opens up wide opportunities in solving a number of important medical problems, including the development of effective cellular and organ cryoprotectants, as well as longterm storage of food products without loss of their consumer properties in the food industry.

Oleinik G.A. , Zhdanova P. , Koval V.V. , Chernonosov A.A. , Baranova S.V.
Structure of an Ice-Binding Protein from Myoxocephalus octodecemspinosus Determined by Molecular Dynamics and Based on Circular Dichroism Spectra
Biophysics. 2023. V.68. N4. P.513-518. DOI: 10.1134/s0006350923040152 Scopus OpenAlex

Закаблук Г.А. , Жданова П.В. , Коваль В.В. , Черноносов А.А. , Баранова С.В.
Структура лед-связывающего белка из Myoxocephalus octodecemspinosus, полученная методом молекулярной динамики и на основе спектров кругового дихроизма
Биофизика. 2023. Т.68. №4. С.640–645. DOI: 10.31857/S0006302923040026 РИНЦ OpenAlex

Accepted:

Feb 15, 2023

Scopus:	2-s2.0-85179975471
OpenAlex:	W4389670799

Пока нет цитирований