8-Oxoadenine: A «New» Player of the Oxidative Stress in Mammals? Обзор
Журнал |
International Journal of Molecular Sciences
, E-ISSN: 1422-0067 |
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Вых. Данные | Год: 2024, Том: 25, Номер: 2, Номер статьи : 1342, Страниц : DOI: 10.3390/ijms25021342 | ||||||||||
Ключевые слова | 7,8-dihydro-8-oxoadenine; mutagenesis; DNA polymerases; base excision repair; DNA glycosylases; translesion DNA synthesis | ||||||||||
Авторы |
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Организации |
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Реферат:
Numerous studies have shown that oxidative modifications of guanine (7,8-dihydro-8-
oxoguanine, 8-oxoG) can affect cellular functions. 7,8-Dihydro-8-oxoadenine (8-oxoA) is another
abundant paradigmatic ambiguous nucleobase but findings reported on the mutagenicity of 8-oxoA
in bacterial and eukaryotic cells are incomplete and contradictory. Although several genotoxic studies
have demonstrated the mutagenic potential of 8-oxoA in eukaryotic cells, very little biochemical
and bioinformatics data about the mechanism of 8-oxoA-induced mutagenesis are available. In this
review, we discuss dual coding properties of 8-oxoA, summarize historical and recent genotoxicity
and biochemical studies, and address the main protective cellular mechanisms of response to 8-oxoA.
We also discuss the available structural data for 8-oxoA bypass by different DNA polymerases as
well as the mechanisms of 8-oxoA recognition by DNA repair enzymes.
Библиографическая ссылка:
Kruchinin A.A.
, Kamzeeva P.N.
, Zharkov D.O.
, Aralov A.V.
, Makarova A.V.
8-Oxoadenine: A «New» Player of the Oxidative Stress in Mammals?
International Journal of Molecular Sciences. 2024. V.25. N2. 1342 . DOI: 10.3390/ijms25021342 WOS Scopus OpenAlex
8-Oxoadenine: A «New» Player of the Oxidative Stress in Mammals?
International Journal of Molecular Sciences. 2024. V.25. N2. 1342 . DOI: 10.3390/ijms25021342 WOS Scopus OpenAlex
Даты:
Опубликована в печати: | 22 янв. 2024 г. |
Идентификаторы БД:
Web of science: | WOS:001150922500001 |
Scopus: | 2-s2.0-85183376672 |
OpenAlex: | W4391104467 |
Цитирование в БД:
Пока нет цитирований