8-Oxoadenine: A «New» Player of the Oxidative Stress in Mammals?

8-Oxoadenine: A «New» Player of the Oxidative Stress in Mammals? Review

Journal

International Journal of Molecular Sciences
, E-ISSN: 1422-0067

Output data

Year: 2024, Volume: 25, Number: 2, Article number : 1342, Pages count : DOI: 10.3390/ijms25021342

Tags

7,8-dihydro-8-oxoadenine; mutagenesis; DNA polymerases; base excision repair; DNA glycosylases; translesion DNA synthesis

Authors

Kruchinin Alexander A. ^1,2 , Kamzeeva Polina N. ^1,3 , Zharkov Dmitry O. ^4,5 , Aralov Andrey V. ³ , Makarova Alena V. ^1,2

Affiliations

1	Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilova St., 119334 Moscow, Russia
2	National Research Center, Kurchatov Institute, Kurchatov sq. 2, 123182 Moscow, Russia
3	Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, 117997 Moscow, Russia
4	Department of Natural Sciences, Novosibirsk State University, 1 Pirogova St., 630090 Novosibirsk, Russia
5	Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8 Lavrentieva Ave., 630090 Novosibirsk, Russia

Numerous studies have shown that oxidative modifications of guanine (7,8-dihydro-8- oxoguanine, 8-oxoG) can affect cellular functions. 7,8-Dihydro-8-oxoadenine (8-oxoA) is another abundant paradigmatic ambiguous nucleobase but findings reported on the mutagenicity of 8-oxoA in bacterial and eukaryotic cells are incomplete and contradictory. Although several genotoxic studies have demonstrated the mutagenic potential of 8-oxoA in eukaryotic cells, very little biochemical and bioinformatics data about the mechanism of 8-oxoA-induced mutagenesis are available. In this review, we discuss dual coding properties of 8-oxoA, summarize historical and recent genotoxicity and biochemical studies, and address the main protective cellular mechanisms of response to 8-oxoA. We also discuss the available structural data for 8-oxoA bypass by different DNA polymerases as well as the mechanisms of 8-oxoA recognition by DNA repair enzymes.

Kruchinin A.A. , Kamzeeva P.N. , Zharkov D.O. , Aralov A.V. , Makarova A.V.
8-Oxoadenine: A «New» Player of the Oxidative Stress in Mammals?
International Journal of Molecular Sciences. 2024. V.25. N2. 1342 . DOI: 10.3390/ijms25021342 WOS Scopus OpenAlex

Published print:

Jan 22, 2024

Web of science:	WOS:001150922500001
Scopus:	2-s2.0-85183376672
OpenAlex:	W4391104467

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